Aromasin is the brand name of the drug exemestane that belongs to the class of drugs aromatase inhibitors (anti-estrogen).
Aromatase is an enzyme that trigger the synthesis of estrogen inside the body and that estrogen could cause the elevation of estrogenic positive or estrogenic responsive or hormonal responsive breast cancer inpost-menopausal women.
Aromasin tend to inhibit the activity of aromatase and causes its antagonism and in turn reduce the production of estrogen,as a result there is declination in the production of cancerous cells that are estrogenic positive.
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It is use as an adjuvant therapy to tamoxifen for the treatment of breast cancer that occur after menopause.
LEGITIMACY OF AROMASIN:
The drug aromasin was 1st approved by US FDA in 1999 and then registered in October 2005 for the treatment of breast cancer of post-menopausal women following the therapy of nolvadex.It was 1st manufactured by Pharmacia and Upjohn but now Pfizer is on top of the list for the production of exemestane (aromasin).
It is legal as therapeutic agent being used under a medical supervision.
MECHANISM OF ACTION:
Aromasin is an oral steroidal aromatase inhibitor, aromatase enzyme causes the conversion of testosterone into estrogen and decrease the reuptake of estrogen in to storage sites and causes the increase concentration of estrogen in plasma, blood circulation and peripheral tissues (esp.in the tissues of breast) this mechanism mainly occur in post-menopausal women.
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Due to the activity of aromatase estrogen produced mostly on peripheral tissues not on its natural sites that is ovary and that abnormal production of estrogen at the ectopic sites causes the development and progression of breast cancer.
Aromasin causes the suicidal inhibition of aromatase enzyme by competitively binding to the target site on which aromatase acts and proceed the conformational change for the production of estrogen. It mimics the structure of natural substrate.
Aromasin is type I-inhibitor of aromatase enzyme use effectively for the estrogen or hormone positive / responsive breast cancer.
The estrogen suppression rate of aromasin vary according to the structure of estrogen, this is known as structure activity relationship.it vary 30% for estradiol and 70 % for estrone.
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Aromasin is steroidal in nature itself while type II inhibitor of aromatase enzyme such as letrozole etc. are non-steroidal inhibitors.
CYCLE OF AROMASIN:
Aromasin cannot be categorized for the use of three levels of users such as beginners, intermediates and advanced because it is not the basic steroidal drug for performance enhancement but it is used as an ancillary drug for subsiding the estrogenic effects produced by the excessive use of anabolic steroids that have been aromatize inside the body to trigger the greater estrogen concentration.
Along with its estrogenic declining property aromasin is also capable of increasing the testosterone level that effect could be use in its post cycle therapy of steroids to re balance the suppress testosterone level.
For estrogen control on cycle therapy aromasin is so effective to use but at a particular dosage pattern that could be tolerated also dependent upon the factor of use of anabolic steroid. The general range of aromasin is from 12.5mg to 25mg daily
Female aromasin users are those that are body builders and feeling difficulty with the elevated estrogen level and having high water retention causing bloating of body parts. Aromasin dose of 12.5 mg are sufficient to counter the effects and conditions.
For post cycle therapy of testosterone suppression 25 to 50 mg of aromasin for 10 days are not only subjected to decrease the estrogen level but also elevate the natural testosterone that was suppressed from axial part of pituitary gland.
Aroamsin also holds an advantage over another aromatase inhibitors that it does not decrease the level of HDL (cardio protective) cholesterol inside the circulation.
The initial dosage is depending upon the aromatase active compound that the person is on and also dependent upon the tolerance level of the patient.
Best starting dose is 12.5mg every day and the maintenance dose 25mg every other day.
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In case of post cycle therapy of steroidal anabolic dose may range from 25 mg to 50 mg for 10 days in most of the males.
ADVERSE EFFECTS OF AROMASIN:
The most common side effects related to aromasin therapy produce due to the low estrogenic concentration that mostly include hot flushes, vasodilation of skin vessels,excessive sweating.
Other common side effects associated with aromasin therapy are headache,nausea, diarrhea, insomnia and joints pain that are mostly happened in the cases of advanced breast cancer patients.
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Lymphopenia (decrease in lymphocytes count) may also be seen to observe in rare cases.
With the advanced doses of aromasin few androgenic side effects are appeared such as weight gain and acne,facial hair growth etc.
Depression ,anxiety, mood changes ,bone fractures,vaginal bleeding and itching ,hair loss,dark urine ,yellowish eyes ,trouble sleeping ,dizziness,all are need to be reported to doctor if start to appear any one of these.
It causes sever joints pain in few females because of excessive dryness of bones and ligaments.
EFFECTS OF AROMASIN:
Aromasin is use for the treatment of early breast cancer occurred in post-menopausal women who were at early treatment of tamoxifen.it is also use as an adjuvant therapy to the advanced breast cancer in women after menopause.
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It is also use by anabolic steroids users in order to counter the estrogenic side effects such as gynecomastia and feminine characters produce by increase concentration of estrogen due to the activity of aromatase enzyme.
This aromasin causes the inhibition of aromatase enzyme that inturn decrease the level of estrogen.
It is best over other aromatase inhibitors to re gain the level of natural testosterone that was suppressed form the pituitary gland and the brain.
ONLINE BUYING OF PRODUCT:
The prescription is needed in all states for the purchasing of aromasin. A very affordable site ag-guys.com is there for the online purchasing of aromasin that is in liquid form and is of good quality.
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Black market sites are also there but they sold out illegal fake drugs and they produce their hidden adverse effects rather than producing therapeutic effects.